Electrospinning & electrospraying technology - Bioinicia
1521
page-template,page-template-full_width,page-template-full_width-php,page,page-id-1521,ajax_fade,page_not_loaded,,qode-title-hidden,qode_grid_1300,side_menu_slide_from_right,footer_responsive_adv,hide_top_bar_on_mobile_header,qode-theme-ver-11.1,qode-theme-bridge,wpb-js-composer js-comp-ver-5.1.1,vc_responsive
Electrohydrodynamic Processing EHDP

Electrohydrodynamic Processing

EHDP, also commonly referred to as electrospinning (for fibers) or electrospraying (for particles), is the voltage-driven fabrication technology at the core of Bioinicia’s Fluidnatek ® equipment range. These processes have been Investigated thoroughly in academia over the last 25 years as a means to fabricate nano and/or micro-structured fibers and particles and are now being adopted by industry for a broad range of applications. The electrospinning process as well as electrospraying are becoming an advantageous option in some industrial applications replacing other traditional techniques used so far such as the spray-drying or the lyophilization because of the special benefits and distinguishing characteristics that electrospinning and electrospraying provide.

There are several key characteristics which differentiate this technology from alternative processes:

– Produces dry product in a single step (powder or non-woven fiber membranes, coatings and complex shapes)

– Room temperature operation suitable for processing labile components e.g. antioxidants, living cells, pharmaceutical ingredients, omega-3 oils, etc…

– Suitable for an extensive portfolio of materials, including polymers, proteins, inorganic materials and composites, providing the flexibility to tailor the products’ properties according to the application requirements

– Capable of producing single-phase or multi-component fibers and particles e.g. blended or core-shell structures (being the coaxial electrospinning one of the most well- known processes of interest for researchers)

Coaxial electrospinning is doable with a single-nozzle injector but also using a multi-nozzle spinning head, in order to produce larger batches

– Enables high efficiency encapsulation of bioactive ingredients or functional compounds

The electrospinning process (as well as the electrospraying process) gets to dry and encapsulate in just one single step

– Tightly controlled fiber and particle dimensions (50nm to 10um range)

– Continuous production process allows for industrial scalability

– Low energy-consumption compared with other drying processes

– Can be used within cleanroom facilities and validated for GMP or ISO13485 processing

Electrospinning

  • 01

    Preparation of solution

    polymer / protein + solvent + functional components
    High viscosity : molecular chain entanglement

  • 02

    Electrospinning

    Feeding of solution through capillaries
    Application of high voltage
    Formation of jet
    Jet whipping : jet stretches into fibers
    Solvent evaporation

  • 03

    Dry fiber collection

    Stationary plate, rotating mandrel, high-speed rotating drum or custom geometry

Electrospraying

  • 01

    Preparation of solution

    polymer / protein + solvent + functional components
    Low viscosity : low degree of entanglement

  • 02

    Electrospinning

    Feeding of solution through capillaries
    Application of high voltage
    Formation of jet
    Jet atomisation : jet breaks up into droplets
    Solvent evaporation

  • 03

    Dry fiber collection

    Stationary plate or custom geometry

Materials

Types of material structures which can be obtained

  • Single-phase: simple fiber / particle – can be single material or blend
    • Easiest process
    • When used for encapsulation, usually results in burst release + diffusion/dissolution driven release
  • Coaxial: By doing coaxial electrospinning, it enables core-shell structures of fibers or particles, where a core of one material is encapsulated within a shell of another
    • Separates incompatible ingredients until encapsulation
    • Encapsulation of high-value or perishable ingredients
    • Processing of unspinnable / insoluble materials
    • Control of bioactive release profiles and elimination of burst release stage

Advantages of Bioinicia’s Fluidnatek® Technology

  • Wide range of materials can be processed (polymers, biopolymers, bioactives, inorganic precursors…), including those requiring volatile organic solvents
  • Fabrication of fibers and particles
  • Flexibility over material structure: single-phase, blends and core-shell structures (by coaxial electrospinning or even multi-axial electrospinning) possible in both fibers and particles
  • Depositions can be collected as continuous non-woven, aligned fibers and complex 3D shapes
  • Both the electrospinning process and electrospraying process allow a tight control over fiber / particle size and morphology
  • Suited to small-scale R&D and scalable to meet industrial needs
  • Safe design prevents accumulation of electrostatic charge and eliminates risk of shock
  • Climate conditioning maintains stable processing conditions for reproducible results
  • Can be used in cleanroom environment and qualified for GMP and ISO13485 processes
  • Possibility of carrying out direct writing/patterning techniques thanks to the 3D motion and module for trajectories insertion of the spinning head (exclusive feature of Fluidnatek® technology integrated in the Fluidnatek LE-100 machine as an optional ability)
  • Special design for solvent vapours extraction, allowing maximum safety and avoiding any risk of explosion in the experimental chamber. Actively regulated exhaust system also available to prevent the solvent vapours from escaping out the experimental chamber even when opening the door while the electrospinning process is running
Advantages

Do you want to know all we can for you?