Electrospinning & electrospraying technology - Bioinicia
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Electrohydrodynamic Processing EHDP

Electrohydrodynamic Processing

EHDP, also commonly referred to as electrospinning (for fibers) or electrospraying (for particles), is the voltage-driven fabrication technology at the core of Bioinicia’s Fluidnatek® equipment range. These processes have been Investigated thoroughly in academia over the last 25 years as a means to fabricate nano and/or micro-structured fibers and particles and are now being adopted by industry for a broad range of applications.

There are several key characteristics which differentiate this technology from alternative processes:

– Produces dry product in a single step (powder or non-woven fiber membranes, coatings and complex shapes)

– Room temperature operation suitable for processing labile components e.g. antioxidants, living cells, pharmaceutical ingredients, omega-3 oils, etc…

– Suitable for an extensive portfolio of materials, including polymers, proteins, inorganic materials and composites, providing the flexibility to tailor the products’ properties according to the application requirements

– Capable of producing single-phase or multi-component fibers and particles e.g. blended or core-shell structures

– Enables high efficiency encapsulation of bioactive ingredients or functional compounds

– Tightly controlled fiber and particle dimensions (50nm to 10um range)

– Continuous production process allows for industrial scalability

– Low energy-consumption compared with other drying processes

– Can be used within cleanroom facilities and validated for GMP or ISO13485 processing

Electrospinning

  • 01

    Preparation of solution

    polymer / protein + solvent + functional components
    High viscosity : molecular chain entanglement

  • 02

    Electrospinning

    Feeding of solution through capillaries
    Application of high voltage
    Formation of jet
    Jet whipping : jet stretches into fibers
    Solvent evaporation

  • 03

    Dry fiber collection

    Stationary plate, rotating mandrel, high-speed rotating drum or custom geometry

Electrospraying

  • 01

    Preparation of solution

    polymer / protein + solvent + functional components
    Low viscosity : low degree of entanglement

  • 02

    Electrospinning

    Feeding of solution through capillaries
    Application of high voltage
    Formation of jet
    Jet atomisation : jet breaks up into droplets
    Solvent evaporation

  • 03

    Dry fiber collection

    Stationary plate or custom geometry

Types of material structures which can be obtained

  • Single-phase: simple fiber / particle – can be single material or blend
    • Easiest process
    • When used for encapsulation, usually results in burst release + diffusion/dissolution driven release
  • Coaxial: Enables core-shell structures, where a core of one material is encapsulated within a shell of another
    • Separates incompatible ingredients until encapsulation
    • Encapsulation of high-value or perishable ingredients
    • Processing of unspinnable / insoluble materials
    • Control of bioactive release profiles and elimination of burst release stage

Advantages of Bioinicia’s Fluidnatek® Technology

  • Wide range of materials can be processed, including those requiring volatile organic solvents
  • Fabrication of fibers and particles
  • Flexibility over material structure: single-phase, blends and core-shell structures possible in both fibers and particles
  • Depositions can be collected as continuous non-woven, aligned fibers and complex 3D shapes
  • Tight control over fiber / particle size and morphology
  • Suited to small-scale R&D and scalable to meet industrial needs
  • Safe design prevents accumulation of electrostatic charge and eliminates risk of shock
  • Climate conditioning maintains stable processing conditions for reproducible results
  • Can be used in cleanroom environment and qualified for GMP and ISO13485 processes

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