drug_delivery_electrospinning

Electrospinning systems for drug delivery

“A drug-delivery system is defined as a formulation or device that enables the introduction of a therapeutic agent into the body and enhances its efficacy and safety by controlling the rate, time, and site of release within the body”[1]. In recent years, there has been an increasing demand for drug delivery systems that provide a controlled or targeted release of active pharmaceutical ingredients (APIs) in order to maximize treatment efficacy and minimize adverse side-affects by reducing overall dosage. Electrospinning systems for drug delivery applications are one of the most promising technologies being investigated for such purposes.

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Existing technologies, such as spray drying, lyophilisation and emulsification suffer limitations, such as large particle size, uneven particle morphology and wide size distribution, narrow range of encapsulant options, thermal degradation of the bioactive compounds, poor encapsulation efficiency, slow and expensive batch processing, etc. Electrospinning and electrospraying technologies address many of these limitations, providing a simple and scalable room-temperature method to achieve high encapsulation efficiency in either fibers or particles at the micro and nano scale.

An electrospinning system for drug delivery device development allows the formation of fibers, or particles, that can encapsulate drugs either by blending the bioactive ingredient/s into the polymer solution prior to electrospinning, or by coaxial processing to create a core-shell structure. Due to the high surface area-to-volume ratio of such fibers or particles, the APIs loaded within them can be delivered extremely efficiently. The flexibility, in terms of the range of encapsulant materials that can be processed and the structural variations made possible, means that the drug release profiles can be tailored to a specific application, from burst release to sustained delivery. Such electrospun devices can even be designed to release the drug in response to an external stimulus such as pH, temperature, light or ultrasound, and can even be directed to a particular site in the body by incorporation of magnetic material.

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Working with an electrospinning system for drug delivery applications allows the use of a wide range of polymers (both natural and synthetic) and proteins, including collagen, silk fibroin, PCL, PLA, PLGA, chitosan and many more. Electrospun materials are finding application within tissue engineering, regenerative medicine, implant coatings and pharmaceutics. Specifically, drug-loaded nanofibres and particles created by electrospinning and electrospraying are extremely important for applications in antimicrobial wound dressings, cell therapies, novel drug delivery platforms, and anti-cancer drug therapies.

Recent strategies in the field of cancer treatment use electrospinning systems for drug delivery to incorporate specific tumour-binding anti-bodies into electrosprayed nanoparticles to target the delivery of chemotherapy drugs directly to a tumour site and thereby reduce the systemic drug dosage requirements and side-affects typically associated with such treatments. This approach is made possible by electrospraying because of the small particle sizes that are possible and the low temperature processing, which does not degrade the sensitive proteins.

 

About Bioinicia

Bioinicia are specialists in the electrospinning and electrospraying processes (EHD), and world-leading providers of premium-quality, climate-controlled electrospinning and electrospraying equipment.  Offering Contract Research and Development services and Contract Manufacturing of electrospun and electrosprayed materials under GMP certification means that we can assist you at any stage in your drug delivery product development.

Simply leverage our expertise in electrospinning systems for drug delivery applications and the electrospinning/electrospraying processes, from laboratory research to industrial manufacture, and advance the development of your future generation of products to the next level.

What can we do for you?

 

[1] Zamani, M., Prabhakaran, M. P., & Ramakrishna, S. (2013). Advances in drug delivery via electrospun and electrosprayed nanomaterials. International Journal of Nanomedicine8, 2997–3017. http://doi.org/10.2147/IJN.S43575

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