Pharmaceutics - Bioinicia
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There are applications for both electrospun fibers and electrosprayed particles in pharmaceutical products. One of the main uses for these technologies in this field is for the encapsulation and controlled release of active pharmaceutical ingredients (APIs). Both fibers and particles can be used as delivery platforms for APIs into the body, depending on the desired properties of the product and method of application. By considered selection of materials and careful design of the process it is possible to tailor the release profile of the drug to the particular application, from immediate burst release, to sustained release, or even targeted release upon an external trigger e.g. pH change, temperature, ultrasonic, light etc. Moreover, using multi-axial electrospinning or electrospraying can result in multi-layered structures, which can be used to deliver different APIs at different stages. The ability to process such a wide variety of materials, and create a variety of different structures and morphologies makes electrospinning or electrospraying a valuable tool for the development of new drug release platforms.

Another area of research for electrospraying in pharmaceutics is the production of API nanoparticles. Due to the small droplet size generated during electrospraying and the resulting fast evaporation rate of the solvent from the API solution, the API containing solution is dried extremely quickly (without the need for increased temperature). This can lead to reduced drug crystallinity, which in turn can increase the bioavailability of the drug.

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