Regenerative Medicine involves the repair of natural tissues, most often using a structural scaffold which gets populated with living cells, either by adding and growing them with the scaffold in vitro within a bioreactor, or naturally over time within the body. The scaffold provides structural support for the cells to grow and mechanical strength to the body until the damaged tissue is regenerated. The scaffold can be designed to remain in the body permanently, or to be fully resorbed and replaced by the body’s own tissue. Electrospun materials are highly porous, which allows for the passage of nutrients and bi-products to and from the cells throughout the scaffold. The three dimensional network of fibers made possible by electrospinning mimics the structure of the collagen ECM, which leads to natural behavior of the cells growing on it. By designing the material and morphology of the electrospun scaffold, cells can be directed to differentiate in a desired manner, or can be oriented along one axis, e.g. in the case of nerve or tendon repair. Using this approach, researchers have demonstrated the use of electropsun materials for repairing skin, bone, veins, valves, muscle, tendons, nerves and many more.