ADVANTAGES IN PHARMA
Pharma GMP & ISO certified industrial electrospinning and spraying.
Optimize drug performance:
- Size reduction of particles and fibers → Dramatically increased surface area and controlled crystallinity → increase bioavailability.
- Efficient encapsulation → Design of release profile.
Versatile, simple and low impact processing:
- Drying and encapsulation in a single step at room temperature.
- Excellent processability of a wide range of materials.
- Robust and continuous processing.
SUPPORTS ALL ADMINISTRATION ROUTES
ELECTROSPINNING FIBER
NONWOVENS
Muco-adhesive buccal, sublingual, transdermal patch
Oral thin film (OTF)
Subcutaneous insert
Ophthalmic patch
Wound dressing
Soft tissue implant
ELECTROSPRAYING
PARTICLES
Oral
Parental
Inhalation
THINK IN TECHNOLOGY PLATFORMS
THINK IN FUTURE
Mucoadhesive
patch platform &
sublingual patch
platform
Instantly soluble
transdermal
patch
transdermal
patch
Oral Dissolving
Film (ODF/OTF)
Film (ODF/OTF)
Example of our unique mucoadhesive delivery platform for drugs
Rivelin® mucosal drug delivery patch novel administration route with designed release profile
- Developed for the treatment of mucosal lesions e.g. oral lichen planus (6 million patients in USA & Europe)
- Dual-action patch technology that adheres to any mucosal surface
- Provides controlled and efficient uni-directional drug delivery to target area
- Provides soft protective shield that offers instant pain relief and efficient healing
- Currently in Phase 2b clinical trial – 240 patients with oral lichen planus, across 20 site in EU and US
Drug-loaded Layer
- Facing mucosa
- Bio-adhesive
- Hydrophilic
- Biodegradable
Example: Rivelin® mucosal drug delivery patch -> novel administration route
with designed release profile.
with designed release profile.
- Developed for te treatment of mucosal lesions (e.g oral lichen planus)
- Dual-action patch technology that adheres to any mucosal surface.
- Controlled, uni-directional drug delivery to target area.
- Soft protectie shield for instant pain relief and improvedhealing
- Currently in Phase 2b clinical trial – 240 patients with oral lichen planus
Oral Dissolving Film (ODF/OTF)
- Immediate release in the mouth for oral mucosal or gastrointestinal absorption..
- Combination of different APIs in monolayer or multilayer design..
- Flavour masking.
- Increased dissolution rate, permeability and hence bioavailability
- API nanodispersed within excipient microparticles
- High API content within the microparticles, e.g.. >80%
- Prevents API aggregation, recrystallization and polymorphism
- Safe handling during tabletting
Nanonized API in microcapsule (Nano-in-Micro)
Dissolution rate
Effect of formulation and electrospraying process on dissolution rate.
- Nanonized valsartan within microparticles leads to near instantaneous dissolution
Permeability profile
Effect on permeation across caco-2 cell membrane
- Nanonized valsartan showed over 6x increase in permeability compared with pure API
Plasma Concentration
Effect on bioavailability.
- Nanonized valsartan showed a 4.7x increase in systemic exposure compared with pure API