vascular graft electrospinning

Electrospinning for tissue engineering

Electrospinning is a simple and versatile technique for the fabrication of ultrafine fibers from solutions of polymeric and/or bioactive materials. This technique has shown considerable potential in a wide range of fields including biomedical applications, such as drug delivery, wound healing, regenerative medicine and tissue engineering. Electrospinning for tissue engineering has been extensively researched over the last 20-30 years, primarily due to the inherent similarity of electrospun structures to the native extracellular matrix within our tissues and therefore its ability to provide cells with a familiar environment in which to grow.tissue_engineering_electrospinning

Electrospinning is suitable for the fabrication of biocompatible grafts and scaffolds that provide mechanical stability to an injured area of tissue and encourage cell proliferation and tissue regeneration. Electrospun scaffolds have shown potential for regeneration of skin, nerves, bone, blood vessels, ligaments, tendons, cornea and other tissues.

Electrospinning for tissue engineering involves the fabrication of three-dimensional structures to support cell growth. One important aspect in the development of electrospun scaffolds for tissue engineering and regenerative medicine is the pore sizes between fibers, which should be large enough to allow cell migration, the formation of new blood vessels and the diffusion of nutrients to the growing cells. Tissue engineering scaffolds should ideally provide equivalent mechanical properties to the native tissue it replaces and must be biocompatible to avoid any immune or inflammatory responses. By appropriate selection of the material, scaffolds can be designed to either remain within the body, or to be resorbed by the body slowly over time, as the natural tissue function is restored.

vascular_graft_electrospinningOne of the most promising areas of electrospinning for tissue engineering is the development of tissue engineered vascular grafts (TEVGs). Electrospinning enables the collection of randomly oriented or aligned fibers around a mandrel collector, and can create multiple layers each with different properties e.g. fiber diameter, alignment and pore size, which offers flexibility in terms of graft design, mechanical strength and even guidance of cell growth along aligned fibers.

Electrospinning has shown great potential for the creation of scaffolds and implants for tissue engineering and regenerative medicine and with the advances in professional-quality electrospinning equipment capable of be qualified for use in ISO13485 certified production, we are starting to see the first electrospun devices addressing real clinical needs.

About Bioinicia

Bioinicia are specialists in the electrospinning and electrospraying processes (EHD), and world-leading providers of premium-quality, climate-controlled electrospinning and electrospraying equipment.  Offering Contract Research and Development services and Contract Manufacturing of electrospun and electrosprayed materials under GMP certification means that we can assist you at any stage in your drug delivery product development.

Simply leverage our expertise in the electrospinning for tissue engineering, from laboratory research to industrial manufacture, and advance the development of your future generation of products to the next level.

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