10 Jul Bioinicia to build the world´s first industrial plant for electrospray microencapsulation of bioactive ingredients
Bioinicia is to build the world´s first industrial manufacturing plant for the microencapsulation of bioactives by Electrospraying Assisted by Pressurized Gas (EAPG). EAPG is a novel technique that has been developed and patented by Bioinicia to efficiently encapsulate active and pharmaceutical compounds for controlled release. This versatile technology is able to encapsulate hydrophilic or hydrophobic compounds in a wide variety of wall materials, in an easy handling way. EAPG is a reproducible and versatile solution for micronization and microencapsulation can be employed in many applications areas such as pharmaceuticals, cosmetics, functional foods and nutraceuticals and whenever small particles make the difference or in applications where the materials employed are thermo-sensitive to physical-chemical factors.
The current Bioinicia’s enhanced productivity novel technique combines high voltage and pneumatic pressure to achieve high-throughput microencapsulation, ensuring process stability and performance. The microencapsulation and drying process takes place at room conditions in a continuous single step from which free flowing powder is obtained. The powder can have tailor-made properties, with adjustable morphology (bulk density 90 kg/m3-600 kg/m3) and particle size (1-10 microns), ensuring a narrow particle size distribution. This highly advanced technology shows exceptional encapsulation efficiency at room conditions and is therefore ideally suited for the encapsulation of thermo-sensitive ingredients requiring protection against degradation.
One of the main limitations of standard electrospraying is its low productivity, capable of processing only a few millilitres of solution per hour. Bioinicia’s novel technique combines high voltage and pneumatic pressure to achieve high-throughput microencapsulation in a single step. The current EAPG industrial-demonstration facility is able to produce 1- 3 kg of dry power per hour and can be scaled-up to enable the manufacture of tens of kilograms of dry, encapsulated bioactives per hour. EAPG dries and encapsulates in a single and continuous step obtaining powder with particle diameters in the range of 1-10 µm.
Bioinicia already has an in-house EAPG industrial demonstrator at their facilities in Valencia, which is available for conducting trials and development projects for industrial companies interested in investigating the process for the enhancement of their products.
Thanks to the recent announcement of funding by the European Commission, for winning Phase II of H2020´s SME Instrument, Bioinicia will develop and commercialise its own project, Capsultek; an electrospraying plant capable of the mass-production of microparticles consisting of nanocapsules of active ingredient through this patented and modified electrospraying process.
Bioinicia brings together fundamentals, experience and innovative technology expertise as a market leader in electrohydrodynamic processing. Take advantage of solutions for innovative products and processes and secure your lead in the market.
Fig. 1. Figure 1: Scanning electron microscopy (SEM) images of food hydrocolloid ultrathin microcapsules. Scale markers are 30 µm. (J.M.Lagaron et al., 2019)
Bioinicia is a privately-owned company specializing in the development and manufacture of nano and micro-structured materials by electrospinning and electrospraying, offering premium-quality electrospinning/electrospraying equipment, as well as contract materials-development and manufacturing services. Bioinicia’s customers can leverage their expertise at any stage in their product development, from concept to commercialization. In 2017, Bioinicia was the world’s first electrospinning/electrospraying contract manufacturer to be awarded GMP (pharmaceutical) certification, enabling the manufacture of electrospun/electrosprayed products for pharmaceutical applications.
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